Genome-wide gene expression profiling of stress response in a spinal cord clip compression injury model.

ABSTRACT:

Background

The aneurysm clip impact-compression model of spinal cord injury (SCI) is a standard injury model in animals that closely mimics the primary mechanism of most human injuries: acute impact and persisting compression. Its histo-pathological and behavioural outcomes are extensively similar to human SCI. To understand the distinct molecular events underlying this injury model we analyzed global mRNA abundance changes during the acute, subacute and chronic stages of a moderate to severe injury to the rat spinal cord.

Results

Time-series expression analyses resulted in clustering of the majority of deregulated transcripts into eight statistically significant expression profiles. Systematic application of Gene Ontology (GO) enrichment pathway analysis allowed inference o

SUBMITTER: Chamankhah M 

PROVIDER: S-EPMC3846681 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature