Niacin supplementation increases the number of oxidative type I fibers in skeletal muscle of growing pigs.

ABSTRACT:

Background

A recent study showed that niacin supplementation counteracts the obesity-induced muscle fiber switching from oxidative type I to glycolytic type II and increases the number of type I fibers in skeletal muscle of obese Zucker rats. These effects were likely mediated by the induction of key regulators of fiber transition, PGC-1α and PGC-1β, leading to muscle fiber switching and up-regulation of genes involved in mitochondrial fatty acid import and oxidation, citrate cycle, oxidative phosphorylation, mitochondrial biogenesis. The aim of the present study was to investigate whether niacin supplementation causes type II to type I muscle and changes the metabolic phenotype of skeletal muscles in growing pigs.

Results

25 male, 11 wk old crossbred pigs (Danzucht x Pietra

SUBMITTER: Khan M 

PROVIDER: S-EPMC3846775 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature