Parallel evolution of genome structure and transcriptional landscape in the Epsilonproteobacteria.

ABSTRACT:

Background

Gene reshuffling, point mutations and horizontal gene transfer contribute to bacterial genome variation, but require the genome to rewire its transcriptional circuitry to ensure that inserted, mutated or reshuffled genes are transcribed at appropriate levels. The genomes of Epsilonproteobacteria display very low synteny, due to high levels of reshuffling and reorganisation of gene order, but still share a significant number of gene orthologs allowing comparison. Here we present the primary transcriptome of the pathogenic Epsilonproteobacterium Campylobacter jejuni, and have used this for comparative and predictive transcriptomics in the Epsilonproteobacteria.

Results

Differential RNA-sequencing using 454 sequencing technology was used to determine the primary tran

SUBMITTER: Porcelli I 

PROVIDER: S-EPMC3847290 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature