Splice variants of zinc finger protein 695 mRNA associated to ovarian cancer.

ABSTRACT:

Background

Studies of alternative mRNA splicing (AS) in health and disease have yet to yield the complete picture of protein diversity and its role in physiology and pathology. Some forms of cancer appear to be associated to certain alternative mRNA splice variants, but their role in the cancer development and outcome is unclear.

Methods

We examined AS profiles by means of whole genome exon expression microarrays (Affymetrix GeneChip 1.0) in ovarian tumors and ovarian cancer-derived cell lines, compared to healthy ovarian tissue. Alternatively spliced genes expressed predominantly in ovarian tumors and cell lines were confirmed by RT-PCR.

Results

Among several significantly overexpressed AS genes in malignant ovarian tumors and ovarian cancer cell lines, the most sign

SUBMITTER: Juarez-Mendez S 

PROVIDER: S-EPMC3847372 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature