Ontology highlight
ABSTRACT:
SUBMITTER: Spies N
PROVIDER: S-EPMC3847777 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Genome research 20130926 12
Variation in protein output across the genome is controlled at several levels, but the relative contributions of different regulatory mechanisms remain poorly understood. Here, we obtained global measurements of decay and translation rates for mRNAs with alternative 3' untranslated regions (3' UTRs) in murine 3T3 cells. Distal tandem isoforms had slightly but significantly lower mRNA stability and greater translational efficiency than proximal isoforms on average. The diversity of alternative 3' ...[more]