Design of oligothiophene-based tetrazoles for laser-triggered photoclick chemistry in living cells.

ABSTRACT: A 405 nm light-activatable terthiophene-based tetrazole was designed that reacts with a fumarate dipolarophile with the second-order rate constant k2 exceeding 10(3) M(-1) s(-1). The utility of this laser-activatable tetrazole in imaging microtubules in a spatiotemporally controlled manner in live cells was demonstrated.

SUBMITTER: An P 

PROVIDER: S-EPMC3847902 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature