MicroRNAs as tools to predict glucocorticoid response in inflammatory bowel diseases.

ABSTRACT: In spite of the introduction in therapy of highly effective biological agents, glucocorticoids (GCs) are still employed to induce remission in moderate to severe inflammatory bowel diseases (IBD), but considerable inter-individual differences in their efficacy and side effects have been reported. The effectiveness of these drugs is indeed very variable and side effects, particularly severe in pediatric patients, are common and often unpredictable: the understanding of the complex gene regulation mediated by GCs could shed light on the causes of this variability. In this context, microRNAs (miRNAs) represent a new and promising field of research. miRNAs are small non-coding RNA molecules that suppress gene expression at post-transcriptional level, and are fine-tuning regulators of diverse b

SUBMITTER: De Iudicibus S 

PROVIDER: S-EPMC3848142 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature