Association of FAS and FAS ligand genes polymorphism and risk of systemic lupus erythematosus.

ABSTRACT:

Unlabelled

FAS/FASL pathway plays a critical role in maintaining peripheral immune tolerance; therefore, the apoptosis genes, Fas and Fas ligand (FasL), could be suitable candidate genes in human SLE susceptibility.

Materials and methods

In this case-control study, 106 SLE patients and 149 sex, age, and ethnicity matched healthy controls were genotyped for the Fas A-670G and FasLC-844T polymorphisms by polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP).

Results

The frequency of -670AA genotype was significantly higher in SLE patients than control group and the risk of SLE was 2.1-fold greater in subjects with AA genotype (P=0.03). The frequency of -670A allele was significantly higher in SLE patients than in controls too (58% versus 4

SUBMITTER: Moudi B 

PROVIDER: S-EPMC3848338 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature