Treatment of idiopathic FSGS with adrenocorticotropic hormone gel.

ABSTRACT:

Background and objectives

Adrenocorticotropic hormone (ACTH) has shown efficacy as primary and secondary therapy for nephrotic syndrome due to membranous nephropathy. The data on using ACTH to treat idiopathic FSGS are limited. This report describes our experience using ACTH for nephrotic syndrome due to idiopathic FSGS in the United States.

Design, setting, participants, & measurements

Twenty-four patients with nephrotic syndrome from idiopathic FSGS were treated with ACTH gel at two academic medical centers between 2009 and 2012, either as part of investigator-initiated pilot studies (n=16) or by prescription for treatment-resistant FSGS (n=8). The primary outcome was remission of proteinuria. The median dose of ACTH was 80 units injected subcutaneously twice weekly. Treat

SUBMITTER: Hogan J 

PROVIDER: S-EPMC3848392 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature