Kidney function and prevalent and incident frailty.

ABSTRACT:

Background and objectives

Kidney disease is associated with physiologic changes that may predispose to frailty. This study sought to investigate whether lower levels of kidney function were associated with prevalent or incident frailty in Cardiovascular Health Study (CHS) participants.

Design, setting, participants, & measurements

CHS enrolled community-dwelling adults age ≥65 years between 1989-1990 and 1992-1993. To examine prevalent frailty, included were 4150 participants without stroke, Parkinson disease, prescribed medications for Alzheimer disease or depression, or severely impaired cognition. To examine incident frailty, included were a subset of 3459 participants without baseline frailty or development of exclusion criteria during follow-up. The primary predictor wa

SUBMITTER: Dalrymple LS 

PROVIDER: S-EPMC3848393 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature