A molecular model of the full-length human NOD-like receptor family CARD domain containing 5 (NLRC5) protein.

ABSTRACT:

Background

Pattern recognition receptors of the immune system have key roles in the regulation of pathways after the recognition of microbial- and danger-associated molecular patterns in vertebrates. Members of NOD-like receptor (NLR) family typically function intracellularly. The NOD-like receptor family CARD domain containing 5 (NLRC5) is the largest member of this family that also contains the largest number of leucine-rich repeats (LRRs).Due to the lack of crystal structures of full-length NLRs, projects have been initiated with the aim to model certain or all members of the family, but systematic studies did not model the full-length NLRC5 due to its unique domain architecture.Our aim was to analyze the LRR sequences of NLRC5 and some NLRC5-related proteins and to build a mode

SUBMITTER: Motyan JA 

PROVIDER: S-EPMC3848420 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature