Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5).

ABSTRACT:

Background

Mitogen-activated protein kinase-activated protein kinase 5 (MK5) is involved in one of the major signaling pathways in cells, the mitogen-activated protein kinase pathway. MK5 was discovered in 1998 by the groups of Houng Ni and Ligou New, and was found to be highly conserved throughout the vertebrates. Studies, both in vivo and in vitro, have shown that it is implicated in tumor suppression as well as tumor promotion, embryogenesis, anxiety, locomotion, cell motility and cell cycle regulation.

Methods

In order to obtain a molecular model of MK5 that can be used as a working tool for development of chemical probes, three MK5 models were constructed and refined based on three different known crystal structures of the closely related MKs; MK2 [PDB: 2OZA and PDB: 3M

SUBMITTER: Lindin I 

PROVIDER: S-EPMC3848485 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature