Genetic variant in fat mass and obesity-associated gene associated with type 2 diabetes risk in Han Chinese.

ABSTRACT:

Background

Genome-wide association study (GWAS) has identified that rs8050136 C/A polymorphism in fat mass and obesity-associated gene (FTO) was associated with the risk of type 2 diabetes (T2D) in Europeans. But this association was abolished after adjustment for body mass index (BMI), suggesting that the effect of rs8050136 on T2D risk might be mediated by BMI in Europeans. However, the findings in subsequent studies were inconsistent among Asian populations. To determine whether rs8050136 polymorphism in FTO is independently associated with the risk of T2D in Chinese, we conducted a case-control study with 2,925 T2D patients and 3,281 controls in Han Chinese.

Results

Logistic regression revealed that the A allele of rs8050136 was significantly associated with an increased

SUBMITTER: Qian Y 

PROVIDER: S-EPMC3848839 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature