Comparative genomics reveals distinct host-interacting traits of three major human-associated propionibacteria.

ABSTRACT:

Background

Propionibacteria are part of the human microbiota. Many studies have addressed the predominant colonizer of sebaceous follicles of the skin, Propionibacterium acnes, and investigated its association with the skin disorder acne vulgaris, and lately with prostate cancer. Much less is known about two other propionibacterial species frequently found on human tissue sites, Propionibacterium granulosum and Propionibacterium avidum. Here we analyzed two and three genomes of P. granulosum and P. avidum, respectively, and compared them to two genomes of P. acnes; we further highlight differences among the three cutaneous species with proteomic and microscopy approaches.

Results

Electron and atomic force microscopy revealed an exopolysaccharide (EPS)-like structure surround

SUBMITTER: Mak TN 

PROVIDER: S-EPMC3848858 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature