Safety and efficacy of an injectable extracellular matrix hydrogel for treating myocardial infarction.

ABSTRACT: New therapies are needed to prevent heart failure after myocardial infarction (MI). As experimental treatment strategies for MI approach translation, safety and efficacy must be established in relevant animal models that mimic the clinical situation. We have developed an injectable hydrogel derived from porcine myocardial extracellular matrix as a scaffold for cardiac repair after MI. We establish the safety and efficacy of this injectable biomaterial in large- and small-animal studies that simulate the clinical setting. Infarcted pigs were treated with percutaneous transendocardial injections of the myocardial matrix hydrogel 2 weeks after MI and evaluated after 3 months. Echocardiography indicated improvement in cardiac function, ventricular volumes, and global wall motion scores. Furthe

SUBMITTER: Seif-Naraghi SB 

PROVIDER: S-EPMC3848875 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature