Long non-coding RNA expression profile in human gastric cancer and its clinical significances.

ABSTRACT:

Background

Long non-coding RNAs (lncRNAs) are prevalently transcribed in the genome yet their potential roles in human cancers are not well understood. The aim of the present study was to determine the lncRNA expression profile in gastric cancer and its potential clinical value.

Methods

The global lncRNA expression profile in gastric cancer was measured by lncRNA microarray. Levels of two representative lncRNAs, H19 and uc001lsz, were confirmed by real-time reverse transcriptase-polymerase chain reaction. The relationship between their levels and clinicopathological factors of patients with gastric cancer was explored. A receiver operating characteristic (ROC) curve was constructed for differentiating gastric cancer from benign gastric diseases.

Results

Total of 135 l

SUBMITTER: Song H 

PROVIDER: S-EPMC3848969 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature