A PARK2 polymorphism associated with delayed neuropsychological sequelae after carbon monoxide poisoning.

ABSTRACT:

Background

Delayed neuropsychological sequelae (DNS) are the most severe and clinically intractable complications following acute carbon monoxide (CO) poisoning. Symptoms of DNS often resemble those of Parkinson's disease (PD), suggesting shared neurological deficits. Furthermore, Parkinson protein 2 (PARK2) mutations are associated with PD and other neurodegenerative diseases. The association signal was detected between PARK2 and DNS after acute CO poisoning in our DNA pooling base genome-wide association study.

Methods

Two PARK2 single nucleotide polymorphisms (SNPs), rs1784594 (C/T allele) and rs1893895 (G/A allele), selected from DNA pooling base genome-wide association study, were genotyped by in 514 CO poisoning patients using polymerase chain reaction restriction frag

SUBMITTER: Liang F 

PROVIDER: S-EPMC3849006 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature