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Carbocyclic 5'-nor "reverse" fleximers. Design, synthesis, and preliminary biological activity.

ABSTRACT: A series of 5'-nor carbocyclic "reverse" flexible nucleosides or "fleximers" have been designed wherein the nucleobase scaffold resembles a "split" purine as well as a substituted pyrimidine. This modification was employed to explore recognition by both purine and pyrimidine metabolizing enzymes. The synthesis of the carbocyclic fleximers and the results of their preliminary biological screening are described herein.

SUBMITTER: Zimmermann SC

PROVIDER: S-EPMC3849035 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

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Carbocyclic 5'-nor "reverse" fleximers. Design, synthesis, and preliminary biological activity.

Zimmermann Sarah C SC Sadler Joshua M JM Andrei Graciela G Snoeck Robert R Balzarini Jan J Seley-Radtke Katherine L KL

MedChemComm 20110701 7

A series of 5'-nor carbocyclic "reverse" flexible nucleosides or "fleximers" have been designed wherein the nucleobase scaffold resembles a "split" purine as well as a substituted pyrimidine. This modification was employed to explore recognition by both purine and pyrimidine metabolizing enzymes. The synthesis of the carbocyclic fleximers and the results of their preliminary biological screening are described herein. ...[more]

PMID: 24312722

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