Notch and VEGF pathways play distinct but complementary roles in tumor angiogenesis.

ABSTRACT:

Background

Anti-angiogenesis is a validated strategy to treat cancer, with efficacy in controlling both primary tumor growth and metastasis. The role of the Notch family of proteins in tumor angiogenesis is still emerging, but recent data suggest that Notch signaling may function in the physiologic response to loss of VEGF signaling, and thus participate in tumor adaptation to VEGF inhibitors.

Methods

We asked whether combining Notch and VEGF blockade would enhance suppression of tumor angiogenesis and growth, using the NGP neuroblastoma model. NGP tumors were engineered to express a Notch1 decoy construct, which restricts Notch signaling, and then treated with either the anti-VEGF antibody bevacizumab or vehicle.

Results

Combining Notch and VEGF blockade led to blood

SUBMITTER: Hernandez SL 

PROVIDER: S-EPMC3849070 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature