JunD/AP1 regulatory network analysis during macrophage activation in a rat model of crescentic glomerulonephritis.

ABSTRACT:

Background

Function and efficiency of a transcription factor (TF) are often modulated by interactions with other proteins or TFs to achieve finely tuned regulation of target genes. However, complex TF interactions are often not taken into account to identify functionally active TF-targets and characterize their regulatory network. Here, we have developed a computational framework for integrated analysis of genome-wide ChIP-seq and gene expression data to identify the functional interacting partners of a TF and characterize the TF-driven regulatory network. We have applied this methodology in a rat model of macrophage dependent crescentic glomerulonephritis (Crgn) where we have previously identified JunD as a TF gene responsible for enhanced macrophage activation associated with sus

SUBMITTER: Srivastava PK 

PROVIDER: S-EPMC3849178 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature