HIV-1 envelope glycoprotein signatures that correlate with the development of cross-reactive neutralizing activity.

ABSTRACT:

Background

Current HIV-1 envelope glycoprotein (Env) vaccines are unable to induce cross-reactive neutralizing antibodies. However, such antibodies are elicited in 10-30% of HIV-1 infected individuals, but it is unknown why these antibodies are induced in some individuals and not in others. We hypothesized that the Envs of early HIV-1 variants in individuals who develop cross-reactive neutralizing activity (CrNA) might have unique characteristics that support the induction of CrNA.

Results

We retrospectively generated and analyzed env sequences of early HIV-1 clonal variants from 31 individuals with diverse levels of CrNA 2-4 years post-seroconversion. These sequences revealed a number of Env signatures that coincided with CrNA development. These included a statistically sho

SUBMITTER: van den Kerkhof TL 

PROVIDER: S-EPMC3849187 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature