The dual role of fragments in fragment-assembly methods for de novo protein structure prediction.

ABSTRACT: In fragment-assembly techniques for protein structure prediction, models of protein structure are assembled from fragments of known protein structures. This process is typically guided by a knowledge-based energy function and uses a heuristic optimization method. The fragments play two important roles in this process: they define the set of structural parameters available, and they also assume the role of the main variation operators that are used by the optimiser. Previous analysis has typically focused on the first of these roles. In particular, the relationship between local amino acid sequence and local protein structure has been studied by a range of authors. The correlation between the two has been shown to vary with the window length considered, and the results of these analyses hav

SUBMITTER: Handl J 

PROVIDER: S-EPMC3849216 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature