Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina.

ABSTRACT: In humans, ingested inorganic arsenic is metabolized to monomethylarsenic (MMA) then to dimethylarsenic (DMA), although in most people this process is not complete. Previous studies have identified associations between the proportion of urinary MMA (%MMA) and increased risks of several arsenic-related diseases, although none of these reported on lung cancer. In this study, urinary arsenic metabolites were assessed in 45 lung cancer cases and 75 controls from arsenic-exposed areas in Cordoba, Argentina. Folate has also been linked to arsenic-disease susceptibility, thus an exploratory assessment of associations between single nucleotide polymorphisms in folate metabolizing genes, arsenic methylation, and lung cancer was also conducted. In analyses limited to subjects with metabolite concent

SUBMITTER: Steinmaus C 

PROVIDER: S-EPMC3849353 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature