Exploring drug-target interaction networks of illicit drugs.

ABSTRACT:

Background

Drug addiction is a complex and chronic mental disease, which places a large burden on the American healthcare system due to its negative effects on patients and their families. Recently, network pharmacology is emerging as a promising approach to drug discovery by integrating network biology and polypharmacology, allowing for a deeper understanding of molecular mechanisms of drug actions at the systems level. This study seeks to apply this approach for investigation of illicit drugs and their targets in order to elucidate their interaction patterns and potential secondary drugs that can aid future research and clinical care.

Results

In this study, we extracted 188 illicit substances and their related information from the DrugBank database. The data process reveal

SUBMITTER: Atreya RV 

PROVIDER: S-EPMC3849475 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature