Ethnic-difference markers for use in mapping by admixture linkage disequilibrium.

ABSTRACT: Mapping by admixture linkage disequilibrium (MALD) is a potentially powerful technique for the mapping of complex genetic diseases. The practical requirements of this method include (a) a set of markers spanning the genome that have large allele-frequency differences between the parental ethnicities contributing to the admixed population and (b) an understanding of the extent of admixture in the study population. To this end, a DNA-pooling technique was used to screen microsatellite and diallelic insertion/deletion markers for allele-frequency differences between putative representatives of the parental populations of the admixed Mexican American (MA) and African American (AA) populations. Markers with promising pooled differences were then confirmed by individual genotyping in both the pa

SUBMITTER: Collins-Schramm HE 

PROVIDER: S-EPMC384950 | biostudies-literature | 2002 Mar

REPOSITORIES: biostudies-literature