Genome-wide modeling of complex phenotypes in Caenorhabditis elegans and Drosophila melanogaster.

ABSTRACT:

Background

The genetic and molecular basis for many intermediate and end stage phenotypes in model systems such as C. elegans and D. melanogaster has long been known to involve pleiotropic effects and complex multigenic interactions. Gene sets are groups of genes that contribute to multiple biological or molecular phenomena. They have been used in the analysis of large molecular datasets such as microarray data, Next Generation sequencing, and other genomic datasets to reveal pleiotropic and multigenic contributions to phenotypic outcomes. Many model systems lack species specific organized phenotype based gene sets to enable high throughput analysis of large molecular datasets.

Results and discussion

Here, we describe two novel collections of gene sets in C. elegans and D. m

SUBMITTER: De S 

PROVIDER: S-EPMC3849582 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature