An expression atlas of human primary cells: inference of gene function from coexpression networks.

ABSTRACT:

Background

The specialisation of mammalian cells in time and space requires genes associated with specific pathways and functions to be co-ordinately expressed. Here we have combined a large number of publically available microarray datasets derived from human primary cells and analysed large correlation graphs of these data.

Results

Using the network analysis tool BioLayout Express3D we identify robust co-associations of genes expressed in a wide variety of cell lineages. We discuss the biological significance of a number of these associations, in particular the coexpression of key transcription factors with the genes that they are likely to control.

Conclusions

We consider the regulation of genes in human primary cells and specifically in the human mononuclear phago

SUBMITTER: Mabbott NA 

PROVIDER: S-EPMC3849585 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature