Decreased bone mineral density in subjects carrying familial defective apolipoprotein B-100.

ABSTRACT:

Context

Although numerous epidemiologic studies have documented associations between osteoporosis and cardiovascular disease, the mechanisms underlying this association remain to be clarified. One hypothesis is that hyperlipidemia may be a common predisposing factor to both atherosclerotic heart disease and bone fragility.

Objective

To evaluate this, we compared bone mineral density (BMD) between subjects with and without the R3500Q APOB mutation, the cause of familial defective apolipoprotein B-100, which has been previously shown to markedly increase low-density lipoprotein cholesterol (LDL-C). We hypothesized that R3500Q carriers would have lower BMD due to lifetime, elevated LDL-C.

Design

This was a a cross-sectional study in the Old Order Amish (OOA) population.<

SUBMITTER: Yerges-Armstrong LM 

PROVIDER: S-EPMC3849668 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature