Overfeeding over 24 hours does not activate brown adipose tissue in humans.

ABSTRACT:

Context

Human brown adipose tissue (BAT) is activated with cold exposure, but it is unknown whether overfeeding activates BAT.

Objective

We determined BAT activation with cold, fasting, and overfeeding and the relationship of BAT activation with future weight change.

Design, setting, participants, and interventions

Sixteen healthy adults were evaluated during energy balance, fasting, and 24 hours of 200% overfeeding. All subjects had a fluorodeoxyglucose-positron emission tomography (PET) scan after exposure to 16°C to determine cold-induced BAT activity (CIBA). The first six subjects had a second PET scan after 36 hours of fasting to establish the lack of BAT activation at 22°C. The other subjects' second PET scan occurred after 24 hours of overfeeding at 22°C but on

SUBMITTER: Schlogl M 

PROVIDER: S-EPMC3849677 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature