Variants in toll-like receptor 9 gene influence susceptibility to tuberculosis in a Mexican population.

ABSTRACT:

Background

The control of Mycobacterium tuberculosis (Mtb) infection begins with the recognition of mycobacterial structural components by toll like receptors (TLRs) and other pattern recognition receptors. Our objective was to determine the influence of TLRs polymorphisms in the susceptibility to develop tuberculosis (TB) in Amerindian individuals from a rural area of Oaxaca, Mexico with high TB incidence.

Methods

We carried out a case-control association community based study, genotyping 12 polymorphisms of TLR2, TLR4, TLR6 and TLR9 genes in 90 patients with confirmed pulmonary TB and 90 unrelated exposed but asymptomatic household contacts.

Results

We found a significant increase in the frequency of the allele A of the TLR9 gene polymorphism rs352139 (A>G) in the g

SUBMITTER: Torres-Garcia D 

PROVIDER: S-EPMC3849691 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature