FGF2-induced effects on transcriptome associated with regeneration competence in adult human fibroblasts.

ABSTRACT:

Background

Adult human fibroblasts grown in low oxygen and with FGF2 supplementation have the capacity to tip the healing outcome of skeletal muscle injury - by favoring regeneration response in vivo over scar formation. Here, we compare the transcriptomes of control adult human dermal fibroblasts and induced regeneration-competent (iRC) fibroblasts to identify transcriptional changes that may be related to their regeneration competence.

Results

We identified a unique gene-expression profile that characterizes FGF2-induced iRC fibroblast phenotype. Significantly differentially expressed genes due to FGF2 treatment were identified and analyzed to determine overrepresented Gene Ontology terms. Genes belonging to extracellular matrix components, adhesion molecules, matrix remod

SUBMITTER: Kashpur O 

PROVIDER: S-EPMC3849719 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature