A pilot study evaluating genetic and environmental factors for postpartum depression.

ABSTRACT:

Objective

To assess the influence of genetic and environmental risk factors upon postpartum depression.

Design

Case-control, prospective study.

Setting

The University of California at San Francisco Obstetric and Gynecology Clinic.

Participants

Mothers screened for postpartum depression six weeks after delivery with the Edinburgh Postnatal Depression Scale and recruited as cases and controls.

Measurements

Eligible subjects completed a series of assessments and a structured clinical interview to confirm diagnosis of depression. Deoxyribonucleic acid was obtained for genotyping of 81 single nucleotide polymorphisms in 12 genes hypothesized to be postpartum depression-related.

Results

Twenty-four cases and 24 controls were eligible for analysis. Three

SUBMITTER: El-Ibiary SY 

PROVIDER: S-EPMC3849876 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature