Defining the contribution of SNPs identified in asthma GWAS to clinical variables in asthmatic children.

ABSTRACT:

Background

Asthma genome-wide association studies (GWAS) have identified several asthma susceptibility genes with confidence; however the relative contribution of these genetic variants or single nucleotide polymorphisms (SNPs) to clinical endpoints (as opposed to disease diagnosis) remains largely unknown. Thus the aim of this study was to firstly bridge this gap in knowledge and secondly investigate whether these SNPs or those that are in linkage disequilibrium are likely to be functional candidates with respect to regulation of gene expression, using reported data from the ENCODE project.

Methods

Eleven of the key SNPs identified in eight loci from recent asthma GWAS were evaluated for association with asthma and clinical outcomes, including percent predicted FEV1, bronch

SUBMITTER: Tulah AS 

PROVIDER: S-EPMC3849932 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature