Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations.

ABSTRACT:

Background

Sperm and testes-expressed Adam genes have been shown to undergo bouts of positive selection in mammals. Despite the pervasiveness of positive selection signals, it is unclear what has driven such selective bouts. The fact that only sperm surface Adam genes show signals of positive selection within their adhesion domain has led to speculation that selection might be driven by species-specific adaptations to fertilization or sperm competition. Alternatively, duplications and neofunctionalization of Adam sperm surface genes, particularly as it is now understood in rodents, might have contributed to an acceleration of evolutionary rates and possibly adaptive diversification.

Results

Here we sequenced and conducted tests of selection within the adhesion domain of sixt

SUBMITTER: Grayson P 

PROVIDER: S-EPMC3849967 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature