Genotyping of human neutrophil antigens (HNA) from whole genome sequencing data.

ABSTRACT:

Background

Neutrophil antigens are involved in a variety of clinical conditions including transfusion-related acute lung injury (TRALI) and other transfusion-related diseases. Recently, there are five characterized groups of human neutrophil antigen (HNA) systems, the HNA1 to 5. Characterization of all neutrophil antigens from whole genome sequencing (WGS) data may be accomplished for revealing complete genotyping formats of neutrophil antigens collectively at genome level with molecular variations which may respectively be revealed with available genotyping techniques for neutrophil antigens conventionally.

Results

We developed a computing method for the genotyping of human neutrophil antigens. Six samples from two families, available from the 1000 Genomes projects, were us

SUBMITTER: Chu HT 

PROVIDER: S-EPMC3849977 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature