Deep brain stimulation as a tool for improving cognitive functioning in Alzheimer's dementia: a systematic review.

ABSTRACT: Deep brain stimulation (DBS) is an established, in selected cases therapeutically effective, non-lesional treatment method delivering current rectangular pulses into dysfunctional brain structures via chronically implanted stimulation electrodes. DBS is a recognized method applied in movement disorders and is increasingly evaluated as a possible therapeutic option for psychiatric diseases such as refractory obsessive-compulsive disorders, Gilles de la Tourette syndrome, major depression, and substance-related addiction. Latest research indicates that DBS may be a method for improving cognitive functions in Alzheimer's dementia (AD). Translational data in healthy and AD animals appear to support this notion. Nevertheless, many aspects remain unclear, particularly with regard to the optimal

SUBMITTER: Hardenacke K 

PROVIDER: S-EPMC3850165 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature