Vitamin D Receptor TaqI Gene Variant in Exon 9 and Polycystic Ovary Syndrome Risk.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is known as a metabolic disorder. The results of recent studies implied that vitamin D receptor (VDR) genetic variants may impact PCOS and insulin resistance in women with PCOS. The aim of the present study was to determine the VDR TaqI gene variant in exon 9 (T/C) (rs731236) in normal controls and patients with PCOS for the first time in Iranian Azeri women.

Materials and methods

In this case control study between April 2011 and June 2012, a total of 76 women aged 18-40 years (38 patients with PCOS and 38 healthy women as normal controls) participated. Genotypes of VDR TaqI in exon 9 (T/C) (rs731236) were determined using the PCR-RFLP method.

Results

The frequencies of VDR TaqI T anc C alleles were 0.605 and 0.395 in cases

SUBMITTER: Bagheri M 

PROVIDER: S-EPMC3850346 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature