Quantitative proteomic analysis in HCV-induced HCC reveals sets of proteins with potential significance for racial disparity.

ABSTRACT:

Background

The incidence and mortality of hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) is higher in African Americans (AA) than other racial/ethnic groups in the U.S., but the reasons for this disparity are unknown. There is an urgent need for the discovery of novel molecular signatures for HCV disease progression to understand the underlying biological basis for this cancer rate disparity to improve the clinical outcome.

Methods

We performed differential proteomics with isobaric labeling tags for relative and absolute quantitation (iTRAQ) and MS/MS analysis to identify proteins differentially expressed in cirrhotic (CIR) and HCC as compared to normal tissues of Caucasian American (CA) patients. The raw data were analyzed using the ProteinPilot v3.0. Search

SUBMITTER: Dillon ST 

PROVIDER: S-EPMC3850534 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature