Functional effect of Saffron supplementation and risk genotypes in early age-related macular degeneration: a preliminary report.

ABSTRACT:

Background

To determine whether the functional effects of oral supplementation with Saffron, a natural compound that proved to be neuroprotective in early age-related macular degeneration, are influenced by complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) risk genotypes.

Methods

Thirty-three early AMD patients, screened for CFH (rs1061170) and ARMS2 (rs10490924) polymorphisms and receiving Saffron oral supplementation (20 mg/day) over an average period of treatment of 11 months (range, 6-12), were longitudinally evaluated by clinical examination and focal electroretinogram (fERG)-derived macular (18°) flicker sensitivity estimate. fERG amplitude and macular sensitivity, the reciprocal value of the estimated fERG amplitude threshold, were the mai

SUBMITTER: Marangoni D 

PROVIDER: S-EPMC3850693 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature