14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila.

ABSTRACT: Antagonism between growth-promoting and stress-responsive signaling influences tissue homeostasis and longevity in metazoans. The transcription factor FoxO is central to this regulation, affecting cell proliferation, stress responses, apoptosis, and longevity. Insulin/IGF signaling promotes FoxO phosphorylation, causing its interaction with 14-3-3 molecules. The consequences of this interaction for FoxO-induced biological processes and for the regulation of lifespan in higher organisms remain unclear. Significant complexities in the effects of 14-3-3 proteins on lifespan have been uncovered in Caenorhabditis elegans, suggesting both positive and negative roles for 14-3-3 proteins in the control of aging. Using genetic and biochemical studies, we show here that 14-3-3epsilon antagonizes Fox

SUBMITTER: Nielsen MD 

PROVIDER: S-EPMC3851013 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature