Drug repositioning for orphan genetic diseases through Conserved Anticoexpressed Gene Clusters (CAGCs).

ABSTRACT:

Background

The development of new therapies for orphan genetic diseases represents an extremely important medical and social challenge. Drug repositioning, i.e. finding new indications for approved drugs, could be one of the most cost- and time-effective strategies to cope with this problem, at least in a subset of cases. Therefore, many computational approaches based on the analysis of high throughput gene expression data have so far been proposed to reposition available drugs. However, most of these methods require gene expression profiles directly relevant to the pathologic conditions under study, such as those obtained from patient cells and/or from suitable experimental models. In this work we have developed a new approach for drug repositioning, based on identifying known dru

SUBMITTER: Molineris I 

PROVIDER: S-EPMC3851137 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature