Genome-wide association study on serum alkaline phosphatase levels in a Chinese population.

ABSTRACT:

Background

Serum alkaline phosphatase (ALP) is a complex phenotype influenced by both genetic and environmental factors. Recent Genome-Wide Association Studies (GWAS) have identified several loci affecting ALP levels; however, such studies in Chinese populations are limited. We performed a GWAS analyzing the association between 658,288 autosomal SNPs and serum ALP in 1,461 subjects, and replicated the top SNPs in an additional 8,830 healthy Chinese Han individuals. The interactions between significant locus and environmental factors on serum ALP levels were further investigated.

Results

The association between ABO locus and serum ALP levels was replicated (P = 2.50 × 10⁻²¹, 1.12 × 10⁻⁵⁶ and 2.82 × 10⁻²⁷ for SNP rs8176720, rs651007 and rs7025162 on ABO locus, respectively). S

SUBMITTER: Li J 

PROVIDER: S-EPMC3851471 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature