Gut microbiota dysbiosis and bacterial community assembly associated with cholesterol gallstones in large-scale study.

ABSTRACT:

Background

Elucidating gut microbiota among gallstone patients as well as the complex bacterial colonization of cholesterol gallstones may help in both the prediction and subsequent lowered risk of cholelithiasis. To this end, we studied the composition of bacterial communities of gut, bile, and gallstones from 29 gallstone patients as well as the gut of 38 normal individuals, examining and analyzing some 299, 217 bacterial 16S rRNA gene sequences from 120 samples.

Results

First, as compared with normal individuals, in gallstone patients there were significant (P < 0.001) increases of gut bacterial phylum Proteobacteria and decreases of three gut bacterial genera, Faecalibacterium, Lachnospira, and Roseburia. Second, about 70% of gut bacterial operational taxonomic units (OT

SUBMITTER: Wu T 

PROVIDER: S-EPMC3851472 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature