Annotation and characterization of the Plasmodium vivax rhoptry neck protein 4 (PvRON4).

ABSTRACT:

Background

The tight junction (TJ) is one of the most important structures established during merozoite invasion of host cells and a large amount of proteins stored in Toxoplasma and Plasmodium parasites' apical organelles are involved in forming the TJ. Plasmodium falciparum and Toxoplasma gondii apical membrane antigen 1 (AMA-1) and rhoptry neck proteins (RONs) are the two main TJ components. It has been shown that RON4 plays an essential role during merozoite and sporozoite invasion to target cells. This study has focused on characterizing a novel Plasmodium vivax rhoptry protein, RON4, which is homologous to PfRON4 and PkRON4.

Methods

The ron4 gene was re-annotated in the P. vivax genome using various bioinformatics tools and taking PfRON4 and PkRON4 amino acid sequences

SUBMITTER: Arevalo-Pinzon G 

PROVIDER: S-EPMC3851475 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature