Association of interleukin-33 gene single nucleotide polymorphisms with ischemic stroke in north Chinese population.

ABSTRACT:

Background

IL-33, an IL-1-like cytokine, is a ligand for IL1RL1, which is an important effector molecule of type 2 T helper responses. Although IL-33/IL1RL1 interaction has been suggested to be important in the development of atherosclerosis, genetic influences of the polymorphisms of IL33 in human ischemic stroke are unclear. The aim of this study was to examine whether the single nucleotide polymorphisms in IL33 are associated with ischemic stroke in Northern Chinese population.

Methods

We used a nested case-control study involving 90 ischemic stroke patients and 270 age-matched, sex-matched and blood pressure-matched non-ischemic stroke controls from a rural population and determined the genotypes of four polymorphisms (rs1929992, rs10975519, rs4742170, rs16924159) in IL3

SUBMITTER: Guo L 

PROVIDER: S-EPMC3851730 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature