Gene expression of sternohyoid and diaphragm muscles in type 2 diabetic rats.

ABSTRACT:

Background

Type 2 diabetes differs from type 1 diabetes in its pathogenesis. Type 1 diabetic diaphragm has altered gene expression which includes lipid and carbohydrate metabolism, ubiquitination and oxidoreductase activity. The objectives of the present study were to assess respiratory muscle gene expression changes in type 2 diabetes and to determine whether they are greater for the diaphragm than an upper airway muscle.

Methods

Diaphragm and sternohyoid muscle from Zucker diabetic fatty (ZDF) rats were analyzed with Affymetrix gene expression arrays.

Results

The two muscles had 97 and 102 genes, respectively, with at least ± 1.5-fold significantly changed expression with diabetes, and these were assigned to gene ontology groups based on over-representation analysis

SUBMITTER: van Lunteren E 

PROVIDER: S-EPMC3851765 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature