Analysis of the microRNA transcriptome and expression of different isomiRs in human peripheral blood mononuclear cells.

ABSTRACT:

Background

MicroRNAs (miRNAs) have been recognized as one of the key regulatory non-coding RNAs that are involved in a number of basic cellular processes. miRNA expression profiling helps to identify miRNAs that could serve as biomarkers. Next generation sequencing (NGS) platforms provide the most effective way of miRNA profiling, particularly as expression of different isoforms of miRNA (IsomiRs) can be estimated by NGS. Therefore, it is now possible to discern the overall complexity of miRNA populations that participate in gene regulatory networks. It is thus important to consider different isoforms of miRNA as part of total profiling in order to understand all aspects of the biology of miRNAs.

Results

Here next generation sequencing data of small RNAs derived from normal

SUBMITTER: Vaz C 

PROVIDER: S-EPMC3851811 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature