Network analysis reveals functional cross-links between disease and inflammation genes.

ABSTRACT: Connections between inflammation and diseases are suggested important in understanding the genetic mechanisms of diseases. However, studies on the functional cross-links between inflammation and disease genes are still in their early stages. We integrated the protein-protein interaction (PPI), inflammation genes, and gene-disease associations to construct a disease-inflammation network (DIN). We found that nodes, which are both inflammation and disease genes (namely inter-genes), are topologically important in the DIN structure. Via mapping inter-genes to PPI, we classified diseases into two categories, which are significantly different in Intimacy measuring the contribution of inflammation genes to the connections between disease pairs. Furthermore, we constructed a cross-talking subpathw

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC3851881 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature