Expression of non-protein-coding antisense RNAs in genomic regions related to autism spectrum disorders.

ABSTRACT:

Background

Autism spectrum disorders (ASD) manifest with neurodevelopmental phenotypes including communicative, social and behavioral impairments that affect as many as 1 in 88 children. The majority of autism cases have no known genetic cause, suggesting complex genetics of the disorder, but a few genes of large effect have been identified.

Methods

In order to identify novel ASD genetic correlates, we investigated non-protein coding RNAs (ncRNAs) which are abundantly transcribed from the human genome, enriched in the brain, and have been implicated in neurodevelopmental disorders. Using an algorithm that we developed, we examined a publicly available transcriptomics database, AceView, to identify the natural antisense transcripts (NATs) that overlap with known autism-relate

SUBMITTER: Velmeshev D 

PROVIDER: S-EPMC3851999 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature