Investigation of anti-cancer mechanisms by comparative analysis of naked mole rat and rat.

ABSTRACT:

Background

The naked mole rats (NMRs) are small-sized underground rodents with plenty of unusual traits. Their life expectancy can be up to thirty years, more than seven times longer than laboratory rat. Furthermore, they are resistant to both congenital and experimentally induced cancer genesis. These peculiar physiological and pathological characteristics allow them to become a suitable model for cancer and aging research.

Results

In this paper, we carried out a genome-wide comparative analysis of rat and NMR using the recently published genome sequence of NMR. First, we identified all the rat-NMR orthologous genes and specific genes within each of them. The expanded and contracted numbers of protein families in NMR were also analyzed when compared to rat. Seven cancer-rel

SUBMITTER: Yang Z 

PROVIDER: S-EPMC3852044 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature